NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. The mean duration of the G-POEM procedure was 72 minutes, with a mean hospital stay of 3.3 days. Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. refractory meaning: 1. not affected by a treatment, change, or process: 2. difficult to control; unwilling to obey…. Refractories definition: unmanageable or obstinate | Meaning, pronunciation, translations and examples See the full definition for refractory in the English Language Learners Dictionary, Thesaurus: All synonyms and antonyms for refractory, Nglish: Translation of refractory for Spanish Speakers. Define Refractory by Webster's Dictionary, WordNet Lexical Database, Dictionary of Computing, Legal Dictionary, Medical Dictionary, Dream Dictionary. home / medterms medical dictionary a-z list / anemia, refractory definition Relapsed and refractory multiple myeloma (MM) constitutes a specific and unmet medical need. Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. An example of something refractory is a material like silica or alumina that are difficult to melt. Source: National Institute of Health. The criteria include the following: 1. 2property of conductive tissue to return to original related state in preparation for a second stimulus. © … Patients with relapsed/refractory disease are defined as those who, having achieved minor resp … View the pronunciation for refractory. (Entry 1 of 2) 1 : resisting control or authority : stubborn, unmanageable. Not readily yielding to treatment. NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. Generally, migraines that are not relieved by acute migraine therapies or prevented by preventive treatments are called refractory migraines, although medical experts have not yet reached a consensus on a precise definition. ungovernable rage intractable suggests stubborn resistance to guidance or control. It stems from the Latin verb refragari, meaning "to oppose.". Once More. Looking for definition of Refractory? 2 a : resistant to treatment or cure a refractory lesion. a willful disregard for the rights of others headstrong suggests self-will impatient of restraint, advice, or suggestion. Typical definitions of TRD vary, and they do not include a resistance to psychological therapies. See more. Learn a new word every day. An example of someone who is refractory is a person who refuses to listen to the rules. MedicineNet does not provide medical advice, diagnosis or treatment. c : immune, insusceptible after recovery they were refractory to infection. by Ka Deans Report definition Refractory in Medical Dictionary Not yielding, or otherwise not yielding readily, to treatment. Myasthenia gravis (MG) is an autoimmune neuromuscular disorder characterized by fatigable muscle weakness. The term high temperatures is somewhat indefinite but usually means above about 1830°F (1000°C), or temperatures at which, because of melting or oxidation, the common metals cannot be used. Refractory epilepsy can have a big effect on your life. Refractory. 1. 1. 2 The first study involved 30 patients with refractory gastroparesis. Treatment-resistant depression (TRD) is a term used in clinical psychiatry to describe a condition that affects people with major depressive disorder (MDD) who do not respond adequately to a course of appropriate antidepressant medication within a certain time. The term high temperatures is somewhat indefinite but usually means above about 1830°F (1000°C), or temperatures at which, because of melting or oxidation, the common metals cannot be used. Introduction: Refractory Description of Refractory. In view of these issues, the term refractory ascites has often generated confusion in the past and made it difficult to compare the results of clinical studies performed by different investigators. “Refractory.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/refractory. [ re-frak´tah-re] 1. not readily yielding to treatment. Introduction: Refractory Description of Refractory. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved. Definition of refractory. 'Nip it in the butt' or 'Nip it in the bud'? (rÄ­-frăk′tə-rē) adj. Conclusions: There is need for a detailed definition of pharmacologically refractory constipation before submitting patients to invasive treatments and to evaluate new pharmacological agents. by Debroah Neiss Report definition. Advertisement The definition of refractory is stubborn or hard to manage, or heat resistant. Then, intractable, the one works best is highlighted in yellow – difficult to alleviate, remedy or cure: intractable pain. The causes, symptoms, and treatment of refractory epilepsy, which develops when your seizures aren't brought under control by medicine. This is the British English definition of refractory.View American English definition of refractory. refractory. If your doctor thinks you have refractory epilepsy, he or she may suggest that you visit a medical center that specializes in epilepsy. intractable opponents of the hazardous-waste dump refractory stresses resistance to attempts to manage or to mold. Learn more. unruly children ungovernable implies either an escape from control or guidance or a state of being unsubdued and incapable of controlling oneself or being controlled by others. These medical condition or symptom topics may be relevant to medical information for Refractory: People with refractory epilepsy may have trouble at work or school. If you've been treated for depression but your symptoms haven't improved, you may have treatment-resistant depression. A refractory symptom may be subjective and, at times, nonspecific. Accessed 30 Nov. 2020. Showing or characterized by obstinate resistance to authority or control: refractory children; refractory behavior. This may present as resistance to treatment from the start, or … acts of sabotage by a recalcitrant populace willful implies an obstinate determination to have one's own way. Refractory cancer refers to cancer that may be resistant at the beginning of treatment, or becomes resistant during treatment. Refractory: Related Topics. One of a number of ceramic materials for use in high-temperature structures or equipment. In some cases, refractory migraine is used synonymously with chronic migraine, or referred to as intractable migraine. The term refractory shock is applied when, in spite of apparently adequate therapy, the shock state continues. Can you spell these 10 commonly misspelled words? These example sentences are selected automatically from various online news sources to reflect current usage of the word 'refractory.' Medical Author: William C. Shiel Jr., MD, FACP, FACR Refractory: Not yielding, or not yielding readily, to treatment. Title: refractory - definition of refractory in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and Encyclop Author: tighe Refractory definition, hard or impossible to manage; stubbornly disobedient: a refractory child. Definition of Refractory. 'All Intensive Purposes' or 'All Intents and Purposes'? Please tell us where you read or heard it (including the quote, if possible). Origin: L. Refractorius This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008) Lexicographical Neighbors of Refractory unruly implies lack of discipline or incapacity for discipline and often connotes waywardness or turbulence of behavior. These medical condition or symptom topics may be relevant to medical information for Refractory: Refractory Myeloma Dr. Damian Green, MD of the Fred Hutchinson Cancer Center, generally defines Refractory Myeloma as: "disease that is progressing despite active treatment." What made you want to look up refractory? 1. It is 2007-12-07ot;difficult” symptoms, since many symptoms considered refractory are at times successfully managed by specialized hospice and palliative care programs (Broeckaert 2002).The malignant tumors most often associated with refractory symptoms include those in the lungs, gastrointestinal tract, head and neck, … A refractory symptom is one that cannot be adequately controlled despite aggressive efforts to identify a tolerable therapy that does not compromise consciousness (Cherny 1994). refractory period the period of depolarization and repolarization of the cell membrane after excitation; during the first portion ( absolute refractory period ), the nerve or muscle fiber cannot respond to a second stimulus, whereas during the relative refractory period it can respond only to a strong stimulus. Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free! special schools for refractory children recalcitrant suggests determined resistance to or defiance of authority. People withrefractory epilepsy may have trouble at work or school. Headaches need to interfere significantly with function or quality of life despite modifica… alteration of refractary, from Latin refractarius, irregular from refragari to oppose, from re- + -fragari (as in suffragari to support with one's vote), Theme music by Joshua Stamper ©2006 New Jerusalem Music/ASCAP. Prior medical therapy was not mentioned at all in five studies. The word “refractory” in general use means stubborn or intractable, and in medicine it is specifically applied to disease that does not respond to treatment. Refractory explanation. [n -RIES] Medical Definition of Refractory. refractory meaning: 1. not affected by a treatment, change, or process: 2. difficult to control; unwilling to obey…. They may also have injuriesthat result from their seizures. Refractory cancer refers to cancer that may be resistant at the beginning of treatment, or becomes resistant during treatment. MG is specifically thought to be an antibody-mediated disease. Change your default dictionary to American English. The word “refractory” in general use means stubborn or intractable, and in medicine it is specifically applied to disease that does not respond to treatment. 2. Some experts define a patient as having refractory seizures if treatment fails to achieve seizure freedom for 12 months or more, for whatever reason (1). The terms refractory shock and irreversible shock are widely used by physicians and other medical workers to refer to types of shock that present particularly difficult problems. Source: National Institute of Health. Refractory: In medicine, describes a disease or condition that does not respond to treatment. Send us feedback. See additional information . Which word describes a musical performance marked by the absence of instrumental accompaniment. conformable, docile, obedient, ruly, submissive, tractable. 2. not responding to a stimulus. 2. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. Delivered to your inbox! G-POEM has been explored in 2 studies and is targeted for patients with gastroparesis refractory to conventional medical treatment. If your doctor thinks you have refractoryepilepsy, he or she may suggest that you visit a medical center thatspecializes in epilepsy. Definition and synonyms of refractory from the online English dictionary from Macmillan Education. One of a number of ceramic materials for use in high-temperature structures or equipment. Resistant to treatment: a refractory case of acne. b : unresponsive to stimulus. https://medical-dictionary.thefreedictionary.com/refractory, Results from the TOWER study, investigating the efficacy of Blincyto versus standard of care chemotherapy in adult patients with Ph- relapsed or, * Devise corrective measures for pipeline projects by understanding, Results: Tests from the paper industry show promise of applicability, but further work is needed to find a nondestructive measure for, Nancy Simonian, chief medical officer of Millennium, said that this filing brings the company a step closer to providing a new treatment option to patients in the European Union with relapsed or, Request TOC of this Report- https://www.factmr.com/connectus/sample?flag=T&rep_id=2518 Dry mix compositions of, Within metalcasting facilities, weekly cleaning tasks such as, Muscat: Strategic and Precious Metals Processing (SPMP), which is building an antimony plant in Sohar, has plans to set up a large, Dictionary, Encyclopedia and Thesaurus - The Free Dictionary, the webmaster's page for free fun content, anemia, sideroblastic, pyridoxine-refractory autosomal recessive, arterial calcification, generalised, of infancy type 2, Demand for refractory products in the United States is projected to increase 2.5 percent per year through 2003 to $2.8 billion, a deceleration from the mid/latter 1990s pace, Amgen Submits Supplemental Biologics License Application for Blincyto Acute Lymphoblastic Leukemia Treatment, "Refractory Multiple Myeloma - Pipeline Review, H2 2013" Published, Hormone Refractory Prostate Cancer - Pipeline Review, H1 2013, Comparing alternate refractory coating measurement systems, EMA accepts filing of MAA for Takeda's ADCETRIS, Global High Temperature Refractory Insulation Material Market Report, 2014-2019 & 2024: Ceramic Fibers, Insulating Fire Bricks, Calcium Silicate, Cement Castables Market Study & Development Insights till 2026, Refractory Technology: Fundamentals and Applications, Remote-controlled demolition machines improve operator safety, Plibrico expands refractory materials sales in the Caribbean, Plans afoot to set up $350m large refractory gold sulphide treatment plant in free zone, refractory cytopenia with multilineage dysplasia, refractory period of electronic pacemaker, Refractory Anemia or Refractory Anemia with Ringed Sideroblasts, Refractory Anemia with Excess Blasts in Transformation, Refractory Anemia with Excess of Myeloblasts, Refractory Anemia with Ringed Sideroblast, Refractory Anemia with Ringed Sideroblasts, Refractory Anemia without an Excess of Blasts. Refractory: Related Topics. The generally accepted definition of refractory seizures was proposed by Berg: failure of two or more drugs and occurrence of one or more seizures per month over 18 months (2). ry. Learn more. Most people chose this as the best definition of refractory: The definition of refract... See the dictionary meaning, pronunciation, and sentence examples. The meaning of refractory cancer is cancer that fails to respond to medical treatment. Refractory in Community Dictionary what's a place where you could check-out get fractORRZZED. The National Cancer Institute breaks it down even further to say that there are two main types of refractory myeloma patients: 1. Many less attractive traits are also recorded: Charles could be uncommunicative and dilatory, evasive and mendacious, These trials routinely focus on those cancers, such as multiple myeloma and, Work is also progressing to explore bone marrow transplants as a novel pathway to treating debilitating conditions like, These fractious workplace relationships aren’t so much the fault of, Another way to reduce what reaches the ground is to substitute, For instance, determining whether a heart attack needs to be urgently catheterized depends in part on if a patient’s chest pain is, Our systematic approach to research enabled the first-ever treatment (siltuximab) and discovery of a treatment for patients who are siltuximab-, Post the Definition of refractory to Facebook, Share the Definition of refractory on Twitter. 1. hard or impossible to manage; stubbornly disobedient: a refractory child. a headstrong young cavalry officer, Refractory is from the Latin word refractarius. Median survival ranges from as little as 6 to 9 months, and responses to treatment are characteristically short. Learn more. Refractory Generalized Myasthenia Gravis (gMG) What is refractory generalized myasthenia gravis (gMG)? Symptoms must be consistent with those defined by the International Classification of Headache Disordersfor migraine or chronic migraine. This may present as resistance to treatment from the start, or … 2. resisting ordinary methods of treatment. Medical Definition of Refractory anemia Medical Author: William C. Shiel Jr., MD, FACP, FACR Refractory anemia : Anemia that is unresponsive to treatment. First it's important to make sure that the diagnosis of epilepsy is correct and that the proper medicines are being used in the best way for each person. Our Word of the Year 'pandemic,' plus 11 more. During the 17th century, it was sometimes spelled as refractary, but that spelling, though more in keeping with its Latin parent, had fallen out of use by the century's end. Refractory and Intractable – The refractory is, when you’re reading the definitions, the one that is the best from medical terms is – resistant to treatment: a refractory case of acne. The importance of defining a refractory symptom is central in utilizing palliative sedation in a safe, efficacious, and ethical manner. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. believing that rules are only for other people, he's been refractory virtually his entire life. Refractory (uncontrolled) epilepsy is a heavy burden. Definition and diagnostic criteria of refractory ascites. The causes, symptoms, and treatment of refractory epilepsy, which develops when your seizures aren't brought under control by medicine. 2 given to resisting control or discipline by others. Symptoms They may also have injuries that result from their seizures. Test Your Knowledge - and learn some interesting things along the way. 3. They may worry alot about when their next seizure will come. unruly, ungovernable, intractable, refractory, recalcitrant, willful, headstrong mean not submissive to government or control. Mosby's Medical Dictionary, 8th edition. believing that rules are only for other people, he's been, One advancement has come in the ability to manufacture. Get Word of the Day delivered to your inbox! They may worry a lot about when their next seizure will come. Difficult to melt or work; resistant to heat: a refractory material such as silica. 3. difficult to fuse, reduce, or work, as an ore or metal. CONTINUE SCROLLING OR CLICK HERE FOR RELATED SLIDESHOW In 2008, the Refractory Headache Special Interest Section (RHSIS) and the American Headache Society (AHS) set out to define criteriafor refractory chronic migraine. Related Sources. Refractory: In medicine, describes a disease or condition that does not respond to treatment. Taking an antidepressant or going to psychological counseling (psychotherapy) eases depression symptoms for most people. Refractory. Refractarius, like refractory, is the result of a slight variation in spelling. 1pertaining to a disorder that is resistant to treatment. The meaning of refractory cancer is cancer that fails to respond to medical treatment. refractory definition: 1. not affected by a treatment, change, or process: 2. difficult to control; unwilling to obey….