Ye G(1), Wang X(1), Tong X(1), Shi Y(1), Fu ZF(1)(2)(3), Peng G(1)(2). Hence, an aprotinin aerosol is already approved in Russia for the treatment of influenza. Curr Pharm Des. See more. 2011 Oct;86(10):1009-26. doi: 10.4065/mcp.2011.0309. The general idea behind modern antiviral drug design is to identify viral proteins, or parts of proteins, that can be disabled. Inhibiting DNA synthesis during viral replication is another approach to battle viral infections. Nucleosides for the treatment of respiratory RNA virus infections. Intracellular metabolism and mechanism of…, Intracellular metabolism and mechanism of action of T-705 against influenza A virus. -, Anand K., Ziebuhr J., Wadhwani P., Mesters J.R., Hilgenfeld R. Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs. Structure of carbocyclic 3-deaza-adenosine (A), neplanocin A (B), 3-deazaneplanocin A (C) and aristeromycin (D). 2007;13(34):3531-42. doi: 10.2174/138161207782794248. These viruses can cause acute, severe illness, including severe respiratory disease, hemorrhagic fever and encephalitis, with a high case fatality rate. Cells. Opin. Ribavirin 5′-monophosphate inhibits the…. Reference: âBoceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main proteaseâ by Chunlong Ma, Michael Dominic Sacco, Brett Hurst, Julia Alma Townsend, Yanmei Hu, Tommy Szeto, Xiujun Zhang, Bart Tarbet, Michael Thomas Marty, Yu Chen and Jun Wang, 15 June 2020, Cell Research. Many antiviral development studies have focused on the possibility of inhibiting the main viral protease (Mpro), and papain-like protease (PLpro), given their central role in viral replication. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error.