Homemade Dog Deterrent By Bibiana da Silva Things You'll Need. Voile, there you have it, a great urine Lastly, shake well to incorporate the ingredients. of cayenne powder. 5. Shake the bottle to mix the cayenne throughout the water. Spray bottle ... To keep your dog away from certain areas in your home and maintain your friendship, try making a natural dog deterrent. Step 1 Pour 1 cup of water into the spray bottle and add 2 tbsp.